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There is the Myasthenia Gravis – Current Treatment Standards and Emerging Drugs 35 enhanced risk of anaphylactic reaction during the application of basiliximab. Other side effects are headaches, anemia, hypertension, obstipation, diarrhea, nausea and infections (Pascual 2001; Kakoulidou 2008). Fig. 14. Basiliximab. 4 hEN101 A novel drug hEN101 (Monarsen®; Fig. 15) is now undergoing the clinical trials. It is a representative of so called “antisense therapy”, where an artificial strand of nucleic acid is designed and prepared to be complementary to mRNA, which transcript is known to be the cause of a disease (Soreq 2006).

4, pp. 1082–1090, ISSN 0021-9738 4 Immunomodulatory Treatments for Myasthenia Gravis: Plasma Exchange, Intravenous Immunoglobulins and Semiselective Immunoadsorption Fulvio Baggi and Carlo Antozzi Neuroimmunology and Muscle Pathology Unit Neurological Institute Foundation “Carlo Besta”, Milan Italy 1. Introduction Myasthenia Gravis (MG) is an autoimmune disorder characterized clinically by fluctuating muscle weakness and fatigability on exertion. The disease is caused by specific autoantibodies against proteins of the neuromuscular junction (NMJ) (Conti-Fine et al, 2002; Sanders & Meriggioli, 2009).

2000). Overview of new immunosuppressive therapy. 2, pp. ; Gjerstad, L. (1988). Sandimun in the treatment of myasthenia gravis. 4, pp. ; Hatanaka, H. (1986) Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same. European patent EP0184162 Oliveto, E. ; Gould, D. H. (1959) Process for the preparation of steroidal dienes and intermediates obtained thereby. ; Ortun~o, J. (2001). Anti-interleukin-2 receptor antibodies: basiliximab and daclizumab. 9, pp.

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