By M. A. D. van Zoelen, A. Achouiti, T. van der Poll (auth.), Prof. Jean-Louis Vincent (eds.)
The Annual replace compiles the latest advancements in experimental and medical study and perform in a single finished reference e-book. The chapters are written by way of good well-known specialists within the box of extensive care and emergency medication. it really is addressed to every body fascinated with inner drugs, anesthesia, surgical procedure, pediatrics, in depth care and emergency medicine.
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Extra info for Annual Update in Intensive Care and Emergency Medicine 2011
Reported that, in patients with septic shock, mRNA S100A12 expression by circulating leukocytes was decreased during the recovery phase . One possible function of S100A12 in host defense during infection and sepsis is its role as a DAMP. NF-κB mediated expression of pro-inflammatory cytokines and upregulation of ICAM-1 and vascular cell adhesion molecule (VCAM)-1 on endothelium has been documented in vitro after S100A12 stimulation . Furthermore, S100A12 could be of benefit for the host during infection and sepsis due to its (more direct) antibacterial activity.
Indeed, HMGB1 is secreted into the circulation after CLP and anti-HMGB1 antibody led to increased survival after CLP-induced peritonitis . In the same surgically (CLP)-induced model of sepsis, RAGE deficiency and anti-RAGE therapy were reported not to affect bacterial outgrowth in the peritoneum, liver, or spleen . Notwithstanding, a possible role of RAGE in antibacterial defense cannot be easily evaluated from this study because host defense against CLP depends, at least in part, on the extent of intestinal necrosis and the formation of a local abscess.
J Pharmacol Exp Ther 324: 664 – 673 23. Varga K, Wagner JA, Bridgen DT, Kunos G (1998) Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension. Faseb J 12: 1035 – 1044 24. Orliac ML, Peroni R, Celuch SM, Adler-Graschinsky E (2003) Potentiation of anandamide effects in mesenteric beds isolated from endotoxemic rats. J Pharmacol Exp Ther 304: 179 – 184 25. Facchinetti F, Del Giudice E, Furegato S, Passarotto M, Leon A (2003) Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide.