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Extra info for 2008 Kaplan USMLE Step 1 Home Study Program-Brand New Volume II: General Principles Book 2

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It is associated with a number of fetal defects, including growth retardation, abnormal brain development and CNS dysfunctions, cardiac abnormalities, facial dysmorphism, and joint defects. 2. Thalidomide is a sedative that was used widely by pregnant women from 1960 to 1962 until it was withdrawn from market. , total or partial absence of extremities), gastrointestinal defects, and cardiac defects. 3. Tetracycline exposure can result in teeth and skeletal abnormalities. 4. Isotretinoin exposure can result in ear, brain, and heart malformations.

LliBhicat 6t Pathology 4. Infections. Virtually all aspects of cellular metabolism are affected by biologic agents infecting the cell. a. Viruses invade cells, commandeer synthetic machinern and may release proteins that are toxic to host cells and cellular metabolism. b. , lipopolysaccharides) from their cell walls. Both cause cell injury and possibly death. c. , IgG, IgM) immunologic reaction to the invader. 5. Irnmunologic reactions. Although the immune response is tightly regulated, it can result in injury as manifested by an anaphylactic reaction or autoimmune diseases.

Both cause cell injury and possibly death. c. , IgG, IgM) immunologic reaction to the invader. 5. Irnmunologic reactions. Although the immune response is tightly regulated, it can result in injury as manifested by an anaphylactic reaction or autoimmune diseases. Direct injurv to an organism can result from the absence of an immune reaction. 6. Genetic disorders, which can present as biochemical abnormalities, can lead to the accumulation of toxic products or the inabiliry to metabolize various compounds due to enzyme defects, such as rystic fibrosis, sickle cell anemia, and Thy-Sachs disease.

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