By J.K. Aronson (Eds.)
The uncomfortable side effects of substances Annual was once first released in 1977. it's been always released given that then, as a every year replace to the voluminous encyclopedia Meyler's unwanted side effects of gear. each one new Annual keeps to supply clinicians and clinical investigators with a competent and significant every year survey of latest facts and tendencies within the zone of difficult Drug Reactions and Interactions. a world group of experts has contributed to the informative, by way of severely examining it, and by way of pointing to no matter what is deceptive. *Provides a serious each year survey of recent info and developments *Special reports during this Annual comprise, between different issues: Epidemiology of using ecstasy, Paracetamol and the chance of bronchial asthma, mix vaccines/multiple immunizations, Interactions of natural drugs with warfarin, and Tyrosine kinase inhibitors.
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Additional info for A worldwide yearly survey of new data and trends in adverse drug reactions
These ﬁndings provide reassur ance about the safety of donepezil in patients taking concomitant cardioactive medications. An 82-year-old patient with Alzheimer’s dis ease developed complete atrioventricular block and a ventricular tachyarrhythmia with dizziness and syncope 1 month after starting donepezil. A temporary ventricular pacing catheter placed in the right ventricle restored sinus rhythm on the fourth day (71A). Nervous system Leg pain has been attrib uted to donepezil (72A). An 85-year-old woman with a 4-year history of Alzheimer’s dementia and glaucoma and hypertension controlled with timolol eyedrops and candesartan, respectively, was given donepezil 5 mg/day, gradually increasing to 10 mg/day; within 10 days of the increase in dose she developed bilateral leg pain, which was continuous, severe in the morning, and reducing in severity by evening, resulting in severe distress.
2. Cone M. Regulatory update: the longawaited MedDRA has arrived! Good Clin Pract J 1999;6(1):42–3. 3. Wood KL. The Medical Dictionary for Drug Regulatory Affairs (MEDDRA) project. Pharmacoepidemiol Drug Saf 1994;3: 7–13. 4. Huntley K, Veverka MJ, Golden M. The FDA’s Medical Dictionary for Drug Regula tory Affairs alpha test. Drug Inf J 1995;29 (4):1133–43. 5. Brown EG, Clark E. Evaluation of MedDRA in representing medicinal product data 6. 7. 8. 9. sheet information. Pharmac Med 1996;10:111–8.
In 11 of these 31 cases there was a positive dechallenge; of these, 1 patient had recurrence of ecchymosis on rechallenge. In the remaining 10 cases with a positive dechallenge, either the outcome of rechal lenge was unknown or rechallenge was not performed. In two of these cases either aspirin or co-trimoxazole had also been used. The time to onset for these events was 1–86 days. Four patients developed bruising within 2 days of starting sibutramine. The case with a positive rechallenge developed ecchymosis 86 days after starting sibutra mine.